Influence of Treg cells on psoriasis

Author: Nino Maisuradze
Keywords: Psoriasis, Treg cells, Immunopathogenesis
Annotation:

Psoriasis is a chronic inflammatory skin disease, which is associated with systemic inflammation and comorbidities, such as psoriatic arthritis and cardiovascular diseases. Affecting about 2% of the population worldwide and is among the most frequent T cell mediated disorders. Common cause of Psoriasis are environmental factors, infectious disease, antibiotics and genetic predisposition. Recently has established autoimmune nature of Psoriasis and different subclasses of T cells are playing key role in immunopathogenesis of the disease. Including Th1 and Th17 cells which are involved in initiation and amplification of the skin inflammation process, furthermore during the cases of recurring Psoriasis Th22 cells are playing the role of memory cells, with the help of Th9 cells, which also are involved in this process. Ongoing studies of psoriasis raise many questions. There is a huge assortment of potential genes involved in the development of the disease and at least the same number of biologically active molecules (chemokines, cytokines, inflammatory mediators, signal transduction and transcription factors). Without a clear understanding of the mechanism of pathogenesis and a thorough understanding of the disease, it is not possible to develop new therapeutic agents and use them optimally. This paper aims to discuss current concepts related to the pathogenesis of the disease and the role of T regulatory cells in the process.