The Isolation and Comparative Study of Mice Bone Marrow Growth-Inhibiting Thermo-Stable Protein Complex

Author: elene tavdishvili
Co-authors: N. Maziashvili, E.Bakuradze. I.Modebadze, L.Rusishvili, N.Bedineishvili, D.Dzidziguri
Keywords: white mice, bone marrow, growth factor, mitotic index
Annotation:

The processes which are the basis of the growth and development of the organisms, such as cell proliferation, differentiation, etc., both in pre- and postnatal periods of ontogenesis, are under control of growth factors. One of such inhibitor of endogenous growth was isolated and partially identified within the thermo-stable protein complex (TPC) in different tissues of adult white rats, including the brain. It has been shown that by inhibiting the transcription it stops the proliferation of the homologous cells; has tissue-specificity regarding to terminally differentiated cells, but does not express species–specificity. At the same time TPC does not affect the proliferational activity of bone marrow in adult, as well as the newborn animals.

Lecture files:

The Isolation and Comparative Study of Mice Bone Marrow Growth-Inhibiting Thermo-Stable Protein Complex [en]
ზრდასრული თაგვების ძვლის ტვინიდან ზრდის შემაკავებელი თერმოსტაბილური ცილების კომპლექსის გამოყოფა და შედარებითი შესწავლა [ka]